ABSTRACT
OBJECTIVE: To describe the factors associated with the requirement of invasive mechanical ventilation (IMV) and mortality in COVID-19 patients diagnosed in a tertiary-care center in Mexico City. MATERIALS AND METHODS: A cross-sectional study was done including consecutive patients with COVID-19 from March 18 to July 30, 2020. RESULT(S): Nine hundred forty-six patients were analyzed. The median age was 53 years (interquartile range, 44-53), 64% men, and 22.2% received invasive mechanical ventilation. The overall mortality was 23.3%, and 50% in the intensive care unit. In the logistic regression analysis, a severe tomographic pattern (STP) (odds ratio [OR] 23.8, 95% confidence interval [95% CI] 6.9-81.3), troponin I > 20 pg/mL (OR 7.1, 95% CI 3.9-12.9) and hyperglycemia (> 180 mg/dL) at admission (OR 2.8, 95% CI 1.6-4.8) were associated with requirement of IMV (p < 0.001). A severe tomographic pattern (OR 18.6, 95% CI 2.5-138.7), troponin I > 20 pg/mL (OR 4.9, 95% CI 3.2-7.4), age between 44-64 years (OR 2.7, 95% CI 1.7-4.1), age >= 65 years (OR 2.9, 95% CI 1.7-5.0), hyperglycemia (OR 1.9, 95% CI 1.2-3.2) and male sex (OR 1.6, 95% CI 1.1-2.4) increased mortality (p < 0.001). CONCLUSION(S): A severe tomographic pattern, high troponin I, and hyperglycemia at admission were associated with invasive mechanical ventilation requirement and increased mortality due to COVID-19.Copyright © 2022 Comunicaciones Cientificas Mexicanas S.A. de C.V.. All rights reserved.